Asymmetric synthesis is one of the most demanding areas of research in the pharmaceutical industry due to the importance of single enantiomers as drug molecules over the racemic mixtures. Asymmetric catalysis, chiral pool synthons, and resolution processes are the major approaches in asymmetric synthesis. Among them, asymmetric catalysis is considered to be the most attractive method due to the requirement of least quantity of chiral source. Recently, organocatalysis has emerged as a new catalytic methodology, where purely organic molecules are used to catalyze chemical reactions. Our group focuses on the development of novel organocatalysts and catalytic methodologies for the asymmetric synthesis of bioactive molecules.

Recent Publications

  • Kumar, R.; Singh, S.; Mehta, R.; Appayee, C.* “Polystyrene-Supported Aminocatalyst Derived from Diarylprolinol for Asymmetric α-Amination of Aldehydes” Eur. J. Org. Chem. 2023, 26, e202300147.

  • Maurya, V.; Kutwal, M. S.; Appayee, C.* “Direct Catalytic Asymmetric Synthesis of Disubstituted 4-Oxocyclohexanecarbaldehydes from Acetone and Cinnamaldehyde DerivativesOrg. Lett. 202123, 1566-1571.

  • Sarkale, A. M.; Appayee, C.* “Stereodivergent Synthesis of 1-Hydroxymethylpyrrolizidine Alkaloids” Org. Lett. 2020, 22, 4355-4359.
  • Kutwal, M. S.; Padmaja, V. M. D.; Appayee, C.* “Regio‐and Enantioselective α,γ‐Dialkylation of α,β‐Unsaturated Aldehydes through Cascade Organocatalysis” Eur. J. Org. Chem. 2020, 2720-2724.
  • Maurya, V.; Appayee, C.* “Enantioselective Total Synthesis of Potent 9β-11Hydroxyhexahydrocannabinol” J. Org. Chem. 2020, 85,1291-1297.

Group Updates

  • Congratulations Rohtash!!!…For Best Poster Award along with 1 year free ACS membership in ACS Ignition Research Showcase.

  • Congratulations Ronak!!!…For Winning First Prize in The Millionairie Quiz, ACS Ignition.

  • Congratulations Navneet!!!… on being awarded prestigious PMRF fellowship.

  • Our research work, “Polystyrene-Supported Aminocatalyst Derived from Diarylprolinol for Asymmetric α-Amination of Aldehydes” is highlighted on the front cover of Eur. J. Org. Chem. 21/2023.

  • Padmaja has successfully defended her PhD thesis on June 2022.

  • Indian Patent (Patent No. 391941) was granted for our invention, “Method for the asymmetric synthesis of (S)-paraconic acid” on March 2022.

  • Vidyasagar has successfully defended his PhD thesis on June 2021.



Contact Us

Academic Block 4, Office 401A
Indian Institute of Technology Gandhinagar,
Palaj Campus, 
Gujarat – 382355, India
Email  :

Phone : +91 7923952462