Asymmetric synthesis is one of the most demanding areas of research in the pharmaceutical industry due to the importance of single enantiomers as drug molecules over the racemic mixtures. Asymmetric catalysis, chiral pool synthons, and resolution processes are the major approaches in asymmetric synthesis. Among them, asymmetric catalysis is considered to be the most attractive method due to the requirement of least quantity of chiral source. Recently, organocatalysis has emerged as a new catalytic methodology, where purely organic molecules are used to catalyze chemical reactions. Our group focuses on the development of novel organocatalysts and catalytic methodologies for the asymmetric synthesis of bioactive molecules.

Recent Publications

  • Maurya, V.; Kutwal, M. S.; Appayee, C.* Direct Catalytic Asymmetric Synthesis of Disubstituted 4-Oxocyclohexanecarbaldehydes from Acetone and Cinnamaldehyde DerivativesOrg. Lett. 202123, 1566-1571.

  • Sarkale, A. M.; Appayee, C.* “Stereodivergent Synthesis of 1-Hydroxymethylpyrrolizidine Alkaloids” Org. Lett. 2020, 22, 4355-4359.
  • Kutwal, M. S.; Padmaja, V. M. D.; Appayee, C.* “Regio‐and Enantioselective α,γ‐Dialkylation of α,β‐Unsaturated Aldehydes through Cascade Organocatalysis” Eu. J. Org. Chem. 2020, 2720-2724.
  • Maurya, V.; Appayee, C.* “Enantioselective Total Synthesis of Potent 9β-11Hydroxyhexahydrocannabinol” J. Org. Chem. 2020, 85,1291-1297.

Group Updates

  • Vidyasagar presented his research work in first virtual XVI J-NOST conference at Indian Institute of Science, Bangalore.

  • Mahesh has successfully defended his PhD thesis on 31st July 2020.

  • Mahesh received ACS Best Poster Award at the International Conference on Recent Trends in Catalysis RTC 2020.

  • Abhijeet presented his research work in XV J-NOST conference at University of Delhi.

  • Mahesh’s work is highlighted in Synfacts 2019, 15, 0797.

  • Research work of Mahesh was among the most downloaded article by the readers of Organic Letters in the month of April 2019.

  • Mahesh presented his research work in XIV J-NOST conference at CSIR-IICT, Hyderabad.

  • Padmaja work is featured in a themed collection “New Talent 2019”.


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Indian Institute of Technology Gandhinagar,
Palaj Campus, 
Gujarat – 382355, India
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Phone : +91 7923952462