Introduction
Asymmetric synthesis is one of the most demanding areas of research in the pharmaceutical industry due to the importance of single enantiomers as drug molecules over the racemic mixtures. Asymmetric catalysis, chiral pool synthons, and resolution processes are the major approaches in asymmetric synthesis. Among them, asymmetric catalysis is considered to be the most attractive method due to the requirement of least quantity of chiral source. Recently, organocatalysis has emerged as a new catalytic methodology, where purely organic molecules are used to catalyze chemical reactions. Our group focuses on the development of novel organocatalysts and catalytic methodologies for the asymmetric synthesis of bioactive molecules.
Recent Publications
- Singh, S.; Kumar, R.; Dubey, N.; Appayee, C.* “Synthesis and Application of Chiral cis-2,5-Disubstituted Pyrrolidine Organocatalysts” Chem. Commun. 2024, Article ASAP.
- Mehta, R.; Kumar, R.; Singh, S.; Appayee, C.* “Asymmetric Synthesis of α-Arylcyclohexenones Catalyzed by Diphenylprolinol Silyl Ether” J. Org. Chem. 2024, Article ASAP.
- Kumar, R.; V, Maurya; A, Avinash; Appayee, C.* “Nonsilyl Bicyclic Secondary Amine Catalysts for the Asymmetric Transfer Hydrogenation of α,β-Unsaturated Aldehydes” J. Org. Chem. 2024, 89, 8586–8600.
- Kumar, R.; Singh, S.; Mehta, R.; Appayee, C.* “Polystyrene-Supported Aminocatalyst Derived from Diarylprolinol for Asymmetric α-Amination of Aldehydes” Eur. J. Org. Chem. 2023, 26, e202300147.
- Maurya, V.; Kutwal, M. S.; Appayee, C.* “Direct Catalytic Asymmetric Synthesis of Disubstituted 4-Oxocyclohexanecarbaldehydes from Acetone and Cinnamaldehyde Derivatives” Org. Lett. 2021, 23, 1566–1571.
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Contact Us
Academic Block 4, Office 401A
Indian Institute of Technology Gandhinagar,
Palaj Campus, Gandhinagar
Gujarat – 382355, India
Email : a.chandra@iitgn.ac.in
Phone : +91 7923952462