Asymmetric synthesis is one of the most demanding areas of research in the pharmaceutical industry due to the importance of single enantiomers as drug molecules over the racemic mixtures. Asymmetric catalysis, chiral pool synthons, and resolution processes are the major approaches in asymmetric synthesis. Among them, asymmetric catalysis is considered to be the most attractive method due to the requirement of least quantity of chiral source. Recently, organocatalysis has emerged as a new catalytic methodology, where purely organic molecules are used to catalyze chemical reactions. Our group focuses on the development of novel organocatalysts and catalytic methodologies for the asymmetric synthesis of bioactive molecules. We also study the bioactivity of small molecules in targeted diseases in collaboration with biological science researchers.

Recent Publications

  • Maurya, V.; Appayee, C.* “Enantioselective Total Synthesis of Potent 9β-11Hydroxyhexahydrocannabinol” J. Org. Chem. 2019, Just Accepted.
  • Sarkale, A. M.; Maurya, V.; Giri, S.; Appayee, C.* “Stereodivergent Synthesis of Chiral Paraconic Acids via Dynamic Kinetic Resolution of 3-Acylsuccinimides” Org. Lett. 201921, 4266–4270.
  • Kutwal, M. S.; Dev, S.; Appayee, C.* “Catalytic Regioselective γ-Methylenation of α,β-Unsaturated Aldehydes Using Formaldehyde via Vinylogous Aldol Condensation” Org. Lett. 2019, 21, 2509–2513.
  • Padmaja, V. M. D.; Jangra, S.; Appayee, C.* “Highly Regioselective α-Alkylation of α,β,γ,δ-Unsaturated Aldehydes” Org. Biomol. Chem. 201917, 1714-1717.

Group Updates

  • Abhijeet presented his research work in XV J-NOST conference at University of Delhi.

  • Mahesh’s work is highlighted in Synfacts 2019, 15, 0797.

  • Research work of Mahesh was among the most downloaded article by the readers of Organic Letters in the month of April 2019.

  • Mahesh presented his research work in XIV J-NOST conference at CSIR-IICT, Hyderabad.

  • Padmaja work is featured in a themed collection “New Talent 2019”.

  • Vidyasagar’s work is highlighted in Synfacts 2018, 14, 0978.

  • Vidyasagar has received best poster award in the 23rd CRSI National Symposium in Chemistry at Indian Institute of Science Education and Research (IISER) Bhopal, India.

  • Mahesh has received best poster award in the 21st CRSI National Symposium in Chemistry at Indian Institute of Chemical Technology, Hyderabad, India.


Contact Us

Academic Block 4, Office 401A
Indian Institute of Technology Gandhinagar,
Palaj Campus, 
Gujarat – 382355, India
Email  :

Phone : +91 7923952462